Post translational modification s-nitrosylation

Similar to phosphorylation, S-Nitrosylation is a reversible precess. The denitrosylation is an enzymatic catalyzing process that reverses the S-Nitrosylation process. However, S-nitrosylation is not a random event, and only specific cysteine residues are S-nitrosylated. Under physiologic conditions, protein S>-nitrosylation and SNOs provide protection preventing further cellular oxidative and nitrosative stress. Aberrant S-Nitrosylation may lead to protein misfolding, synaptic damage, and apoptosis. Dysfunction of the SNO signaling has been implicated in the pathogenesis of many diseases, such as Alzheimer’s disease cardiovascular diseases.