camel discovery

Creative Biolabs provides the unique Native™ service to generate native camel monoclonal antibody for customers all over the world. Camelid, which includes dromedaries, camels, llamas, alpacas, etc., is unique among mammals for producing novel functional antibodies. Other than conventional antibody which is composed of heavy chains and light chains, a unique type of camel antibody is, in contrary, devoid of light chains and merely formed by two identical heavy chains. In addition, these heavy chains are lack of CH1 domain and each heavy chain only contain a single monomeric variable region in Fab domains (Fig. 1), which is called as VHH fragments. These novel camel antibodies are termed as heavy-chain antibodies and count for about 50% of the antibodies in camelids. They are as specific as regular antibodies and in some cases more robust. Due to the VHH fragments and smaller size, camel heavy-chain antibodies are able to transform into bacterial cells easier, which is more ideal for research purposes. With further modification, the VHH fragments can also be developed as single domain antibodies.