Linker design for ADCs is highly dependent on the biolology of the target cells, the characteristics of the antibody, and the structure of the drug molecule. Selection of the optimal linker ...more
Akt, an abbreviated name for protein kinase B (PKB), is a serine/threonine-specific protein kinase that plays a key role in the PI3K/Akt pathway as a regulator for a number of biological processes, ...more
To retain antibody bioactivity, mild, near-physiological conditions are often used for conjugation reactions. Under these conditions, endogenous amino acids such as Lys and Cys are chemically ...more
Designing of an ADC is an elaborate process that involves careful planning, meticulous execution, and intensive trouble-shooting. An effective combination of the most suitable components will ...more
Creative Biolabs has established a state-of-the-art CAR-T library technology based on T cell display. CAR genes with diverse antibody fragments (e.g. scFv, Fab, VHH, scFab) against a certain ...more
Lentiviral (complex retrovirus) transfection is also one of the mainstays of current gene therapy approaches, which enable the integration of artificial genes into the host genome in a stable ...more
Immunotherapy has become a revolution in the area of cancer treatment. Compared to the traditional methods, such as invasive surgeries, radiation and chemotherapy, immunotherapy is more specific ...more